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Hiroshi Ishikita, PhD (Dr. rer. nat.) CV

2015.10.25 BLOGHIROSHI ISHIKITA
石北 央 Hiroshi Ishikita

Professor, The University of Tokyo

Department of Applied Chemistry
Graduate School of Engineering, The University of Tokyo
4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan
hiro☆appchem.t.u-tokyo.ac.jp

Education & Academic Experience

3/1998Bachelor  (Chemistry and Biotechnology, Engineering)
The University of Tokyo, Japan
3/2000Master (Chemistry and Biotechnology, Engineering)
The University of Tokyo, Japan
Adviser: Prof. Teruyuki Nagamune

Germany

6/2000-9/2000DAAD, Deutscher Akademischer Austausch Dienst, Stipendiat (DAAD scholarship holder)
Goethe-Institut Bremen, Germany
10/2000-3/2004DAAD Stipendiat
Freie Universität Berlin (Free University of Berlin), Germany
(Prof. Ernst-Walter Knapp‘s group)
4/2004-12/2005Wissenschaftlicher Mitarbeiter  (Research Associate)
Kristallographie, Institut für Chemie und Biochemie
Freie Universität Berlin (Free University of Berlin), Germany
(Project: Sfb498, A5)
11/2005(thesis: summa cum laude, disputation: summa cum laude, and overall: summa cum laude)
Freie Universität Berlin (Free University of Berlin), Germany
Adviser: Prof. Ernst-Walter Knapp
(2nd Adviser: Prof. Wolfram Saenger)

USA

12/2005-11/2006Postdoctoral Research Associate (Prof. Sharon Hammes-Schiffer‘s group)
Department of Chemistry
The Pennsylvania State University, USA
12/2006- 3/2008Postdoctoral Research Associate (Prof. Arieh Warshel‘s group)
Department of Chemistry
University of Southern California, USA

Japan

4/2008- 12/2008Assistant Professor
Institute of Molecular and Cellular Biosciences
The University of Tokyo, Japan
1/2009- 3/2013Assistant Professor (PI)
Career-Path Promotion Unit for Young Life Scientists
Kyoto University, Japan
3/2013- 6/2013Assistant Professor/Lectuerer (PI)
Career-Path Promotion Unit for Young Life Scientists
Kyoto University, Japan
7/2013- 3/2013Professor
Graduate School of Science
Osaka University, Japan
4/2014-Professor
Graduate School of Engineering
The University of Tokyo

PUBLICATION

  1. Hiroshi Ishikita, Giulia Morra, and Ernst-Walter Knapp*
    Biochemistry 42 (2003) 3882-3892. doi: 10.1021/bi026781t
    “Redox potential of quinones in photosynthetic reaction centers from Rhodobacter sphaeroides: dependence on protonation of Glu-L212 and Asp-L213″
    Journal PubMed
  2. Hiroshi Ishikita and Ernst-Walter Knapp*
    J. Biol. Chem. 278 (2003) 52002-52011. doi: 10.1074/jbc.M306434200
    “Redox potential of quinones in both electron transfer branches of photosystem I”
    Journal PubMed
  3. Hiroshi Ishikita and Ernst-Walter Knapp*
    J. Am. Chem. Soc. 126 (2004) 8059-8064. doi: 10.1021/ja038092q
    “Variation of Ser-L223 Hydrogen bond between Ser-L223 and QB–: protonation of Asp-L213 in the reaction center of Rhodobacter sphaeroides“
    Journal PubMed
  4. Hiroshi Ishikita, Bernhard Loll, Jacek Biesiadka, Artur Galstyan, Wolfram Saenger and Ernst-Walter Knapp*
    FEBS Lett. 579 (2005) 712-716. doi: 10.1016/j.febslet.2004.12.049
    “Tuning electron transfer by ester-group of chlorophylls in bacterial photosynthetic reaction center”
    Journal PubMed
  5. Hiroshi Ishikita and Ernst-Walter Knapp
    J. Am. Chem. Soc. 127 (2005) 1963-1968. doi: 10.1021/ja045058i
    “Redox potentials of chlorophylls and β-carotene in the antenna complexes of photosystem II”
    Journal PubMed
  6. Hiroshi Ishikita and Ernst-Walter Knapp*
    J. Biol. Chem. 280 (2005) 12446-12450. doi: 10.1074/jbc.M413531200
    “Energetics of proton transfer pathways in reaction centers from Rhodobacter sphaeroides. The Glu-H173 activated mutants”
    Journal PubMed
  7. Hiroshi Ishikita, Bernhard Loll, Jacek Biesiadka, Wolfram Saenger and Ernst-Walter Knapp
    Biochemistry 44 (2005) 4118-4124. doi: 10.1021/bi047922p
    “Redox potentials of chlorophylls in the photosystem II reaction center”
    Journal PubMed
  8. Hiroshi Ishikita and Ernst-Walter Knapp*
    FEBS Lett. 579 (2005) 3190-3194. doi: 10.1016/j.febslet.2005.05.004
    “Redox potential of cytochrome c550 in the cyanobacterium Thermosynechococcus elongatus“
    Journal PubMed
  9. Hiroshi Ishikita and Ernst-Walter Knapp*
    J. Am. Chem. Soc. 127 (2005) 14714-14720. doi: 10.1021/ja052567r
    “Control of quinone redox potentials in photosystem II: electron transfer and photoprotection”
    Journal PubMed
  10. Hiroshi Ishikita and Ernst-Walter Knapp*
    Biochemistry 44 (2005) 14772-14784. doi: 10.1021/bi051099v
    “Oxidation of the non-heme iron complex in photosystem II”
    Journal PubMed
  11. Hiroshi Ishikita and Ernst-Walter Knapp*
    Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 16215-16220. doi: 10.1073/pnas.0503826102 [Direct Submission, Edited by H. Gray]
    “Induced conformational changes upon Cd2+ binding at photosynthetic reaction centers”
    Journal PubMed
  12. Hiroshi Ishikita, Dietmar Stehlik, John H. Golbeck and Ernst-Walter Knapp*
    Biophys. J. 90 (2006) 1081-1089. doi: 10.1529/biophysj.105.069781
    “Electrostatic influence of PsaC protein binding to the PsaA/PsaB heterodimer in Photosystem I”
    Journal PubMed
  13. Hiroshi Ishikita, Wolfram Saenger, Bernhard Loll, Jacek Biesiadka, and Ernst-Walter Knapp*
    Biochemistry 45 (2006) 2063-2071. doi: 10.1021/bi051615h
    “Energetics of a possible proton exit pathway for water oxidation in Photosystem II”
    Journal PubMed
  14. Hiroshi Ishikita, Jacek Biesiadka, Bernhard Loll, Wolfram Saenger, and Ernst-Walter Knapp*
    Angew. Chem. 118 (2006) 1998-1999. doi: 10.1002/anie.200503804
    Angew. Chem. Int. Ed. 45     (2006) 1964-1965 doi: 10.1002/anie.200503804
    “Cationic state of accessory chlorophyll and electron transfer through pheophytin to plastoquinone in photosystem II”
    Journal PubMed
  15. Hiroshi Ishikita and Ernst-Walter Knapp*
    Biophys. J.  90 (2006) 3886-3896. doi: 10.1529/biophysj.105.076984
    “Function of redox-active tyrosine in photosystem II”
    Journal PubMed
  16. Hiroshi Ishikita, Wolfram Saenger, Jacek Biesiadka, Bernhard Loll, and Ernst-Walter Knapp*
    Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 9855-9860. [Direct Submission, Edited by H. Gray] doi: 10.1073/pnas.0601446103
    “How photosynthetic reaction centers control oxidation power in chlorophyll pairs P680, P700 and P870”
    Journal PubMed
  17. Hiroshi Ishikita and Ernst-Walter Knapp*
    FEBS Lett. 580 (2006) 4567-4570. doi: 10.1016/j.febslet.2006.07.023
    “Electrostatic role of the non-heme iron complex in bacterial photosynthetic reaction center”
    Journal PubMed
  18. Hiroshi Ishikita*, Bernhard Loll, Jacek Biesiadka, Jan Kern, Klaus-Dieter Irrgang, Athina Zouni, Wolfram Saenger and Ernst-Walter Knapp
    Biochim. Biophys. Acta (Bioenergetics) 1767 (2007) 79-87. doi: 10.1016/j.bbabio.2006.10.006
    “Function of two beta-carotenes near the D1 and D2 proteins in photosystem II dimers”
    Journal PubMed
  19. Hiroshi Ishikita* and Ernst-Walter Knapp
    J. Am. Chem. Soc.129 (2007) 1210-1215. doi: 10.1021/ja066208n
    “Protonation states of ammonia/ammonium in the hydrophobic pore of ammonia transporter protein AmtB”
    Journal PubMed
  20. Irina Karygina, Dietmar Stehlik, Ingelog Wyndhamn, Art van der Est, Hiroshi Ishikita, Ernst-Walter Knapp, Barath Jaganathan, Rufat Agalarov, and John H. Golbeck*
    Biochemistry 46 (2007) 10804-10816.
    “Contributions of the distant protein environment to the redox potentials of the A1 phylloquinone and the FX iron-sulfur cluster in photosystem I”
    Journal PubMed
  21. Hiroshi Ishikita, Alexander V. Soudackov, and Sharon Hammes-Schiffer*
    J. Am. Chem. Soc. 129 (2007)  11146-11152. doi: 10.1021/ja072708k
    “Buffer-assisted proton-coupled electron transfer in a model rhenium-tyrosine complex”
    Journal PubMed
  22. Hiroshi Ishikita*
    FEBS Lett. 581 (2007) 4293-4297. doi: 10.1016/j.bbabio.2007.08.004
    “Modulation of the protein environment in the hydrophilic pore of the ammonia transporter protein AmtB upon the GlnK protein binding”
    Journal PubMed
  23. Hiroshi Ishikita*
    J. Biol. Chem. 282 (2007) 25240-25246.
    “Influence of the protein environment on the redox potentials of flavodoxins from Clostridium beijerinckii“
    Journal PubMed
  24. Hiroshi Ishikita, Artur Galstyan, and Ernst-Walter Knapp*
    Biochim. Biophys. Acta (Bioenergetics) 1767(2007) 1300-1309. doi: 10.1016/j.bbabio.2007.08.004
    “Redox potential of the non-heme iron complex in bacterial photosynthetic reaction center”
    Journal Pubmed
  25. Frank Müh, Mohamed El-Amine Madjet, Julia Adolphs, Ayjamal, Abdurahman, Björn Rabenstein, Hiroshi Ishikita, Ernst-Walter Knapp, and Thomas Renger*
    Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 16862-16867. doi: 10.1073/pnas.0708222104 [Communicated by R. A. Marcus]”alpha-Helices direct excitation energy flow in the Fenna-Matthews-Olson protein”
    Journal Pubmed
  26. Sharon Hammes-Schiffer*, Elizabeth Hatcher, Hiroshi Ishikita, Jonathan Skone, and Alexander V. Soudackov
    Coord. Chem. Rev. 252 (2008) 384-394. doi: 10.1021/bi702151k
    “Theoretical studies of proton-coupled electron transfer: models and concepts relevant to bioenergetics”
    Journal Pubmed
  27. Hiroshi Ishikita and Arieh Warshel*
    Angew. Chem. 120 (2008) 709-712. doi: 10.1002/anie.200704178
    Angew. Chem. Int. Ed. 47     (2008) 697-700. doi: 10.1002/anie.200704178
    “Predicting drug resistant mutations of HIV protease”
    Journal Pubmed
  28. Hiroshi Ishikita*
    Biochemistry 47 (2008) 4394-4402. doi: 10.1021/bi702151k
    “Redox potential difference between Desulfovibrio vulgaris and Clostridium beijerinckii flavodoxins”
    Journal Pubmed
  29. Hiroshi Ishikita*
    J. Biol. Chem. 283 (2008) 30618-30623. doi: 10.1074/jbc.M803864200
    “Light-induced hydrogen bonding pattern and driving force of electron transfer in AppA BLUF domain photoreceptor”
    Journal Pubmed
  30. Hiroshi Ishikita*
    FEBS Lett. 584 (2010) 3464-3468. doi: 10.1016/j.febslet.2010.07.003
    “Origin of the pKa shift of the catalytic lysine in acetoacetate decarboxylase”
    Journal Pubmed
  31. Ana Patricia Gamiz-Hernandez, Gernot Kieseritzky, Hiroshi Ishikita, and Ernst-Walter Knapp*
    J. Chem. Theory Comput. 7 (2011) 742-752. doi: 10.1371/journal.pone.0016920
    “Rubredoxin function: redox behavior from electrostatics”
    Journal Pubmed
  32. Hiroshi Ishikita*
    PLoS One 6 (2011) e16920, 1-7. doi: 10.1371/journal.pone.0016920
    “Proton-binding sites of acid-sensing ion channel 1”
    Journal Pubmed
  33. Hiroshi Ishikita*, Koji Hasegawa, and Takumi Noguchi
    Biochemistry 50 (2011) 5436-5442. doi: 10.1021/bi102023x
    “How does the QB site influence propagate to the QA site in Photosystem II?”
    Journal Pubmed
  34. Hiroshi Ishikita*
    PLoS One 6 (2011) e26808, 1-5. doi: 10.1371/journal.pone.0026808
    “Tyrosine deprotonation and associated hydrogen bond rearrangements in a photosynthetic reaction center”
    Journal Pubmed
  35. Keisuke Saito, Toyokazu Ishida, Miwa Sugiura, Keisuke Kawakami, Yasufumi Umena, Nobuo Kamiya, Jian-Ren Shen, and Hiroshi Ishikita*
    J. Am. Chem. Soc. 133 (2011) 14379-14388. doi: 10.1021/ja203947k
    “Distribution of the cationic state over the chlorophyll pair of photosystem II reaction center”
    Journal Pubmed
  36. Keisuke Saito and Hiroshi Ishikita*
    Biophys. J. 101 (2011) 2018-2025. doi: 10.1016/j.bpj.2011.09.010
    “Cationic state distribution over the P700 chlorophyll pair in Photosystem I”
    Journal Pubmed
  37. Keisuke Saito, Jian-Ren Shen, Toyokazu Ishida, and Hiroshi Ishikita*
    Biochemistry 50 (2011) 9836-9844. doi: 10.1021/bi201366j
    “Short hydrogen-bond between redox-active tyrosine YZ and D1-His190 in the photosystem II crystal structure”
    Journal Pubmed
  38. Keisuke Saito and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 109 (2012) 167-172. doi: 10.1073/pnas.1113599108 [Direct Submission, Edited by A. Fersht]
    “Energetics of short hydrogen bonds in photoactive yellow protein”
    Journal Pubmed
  39. Keisuke Saito, Jian-Ren Shen, and Hiroshi Ishikita*
    Biochim. Biophys. Acta (Bioenergetics) 1817 (2012) 1191-1195. doi: 10.1016/j.bbabio.2011.12.003
    “Cationic state distribution over the chlorophyll d-containing PD1/PD2 pair in photosystem II”
    Journal Pubmed
  40. Hiroshi Ishikita*, Bryan T. Eger, Ken Okamoto, Takeshi Nishino, and Emil F. Pai
    J. Am. Chem. Soc. 134 (2012) 999-1009. doi: 10.1021/ja207173p
    “Protein conformational gating of enzymatic activity in xanthine oxidoreductase”
    Journal Pubmed
  41. Keisuke Saito and Hiroshi Ishikita*
    Biochemistry 51 (2012) 1171-1177. doi: 10.1021/bi201877e
    “H atom positions and nuclear magnetic resonance chemical shifts of short H bonds in photoactive yellow protein”
    Journal Pubmed
  42. Keisuke Saito, Jian-Ren Shen, and Hiroshi Ishikita*
    Biophys. J. 102 (2012) 2634-2640. doi: 10.1016/j.bpj.2012.04.016
    “Influence of the axial ligand on the cationic properties of the chlorophyll pair in photosystem II from Thermosynechococcus vulcanus“
    Journal Pubmed
  43. Keisuke Saito, Yasufumi Umena, Keisuke Kawakami, Jian-Ren Shen, Nobuo Kamiya, and Hiroshi Ishikita*
    Biochemistry 51 (2012) 4290-4299. doi: 10.1021/bi300428s
    “Deformation of chlorin rings in the photosystem II crystal structure”
    Journal Pubmed
  44. Keisuke Saito, Hideki Kandori, and Hiroshi Ishikita*
    J. Biol. Chem. 287 (2012) 34009-34018. doi: 10.1074/jbc.M112.388348
    “Factors that differentiate the H-bond strengths of water near the Schiff bases in bacteriorhodopsin and Anabaena sensory rhodopsin”
    Journal Pubmed
  45. Keisuke Saito and Hiroshi Ishikita*
    Biochim. Biophys. Acta (Bioenergetics) 1827 (2013) 387-394. doi: 10.1016/j.bbabio.2012.11.009
    “Formation of an unusually short hydrogen bond in photoactive yellow protein”
    Journal Pubmed
  46. Keisuke Saito, A. William Rutherford, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 954-959. doi: 10.1073/pnas.1212957110 [Direct Submission, Edited by P. Joliot]
    “Mechanism of proton-coupled quinone reduction in Photosystem II”
    Journal Pubmed
  47. Keisuke Saito, A. William Rutherford, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 7690-7695. doi: 10.1073/pnas.1300817110 [Direct Submission, Edited by H. Gray]
    “Mechanism of Tyrosine D oxidation in Photosystem II”
    Journal Pubmed
  48. Keisuke Saito and Hiroshi Ishikita*
    Biochim. Biophys. Acta (Bioenergetics) 1837 (2014) 159-166. doi: 10.1016/j.bbabio.2013.09.013
    “Influence of the Ca2+ ion on the Mn4Ca conformation and the H-bond network arrangement in Photosystem II”
    Journal Pubmed
  49. Hiroshi Ishikita* and Keisuke Saito
    J. R. Soc. Interface 11(2014) 20130518. doi: 10.1098/rsif.2013.0518
    “Proton transfer reactions and hydrogen-bond networks in protein environments”
    Journal Pubmed
  50. Keisuke Saito, A. William Rutherford, and Hiroshi Ishikita*
    Nat. Commun. 6 (2015) 8488. doi: 10.1038/ncomms9488
    “Energetics of proton release on the first oxidation step in the water-oxidizing enzyme”
    Journal Pubmed
  51. Tomohiro Takaoka, Naoki Sakashita, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 7 (2016) 1925-1932. doi: 10.1021/acs.jpclett.6b00656
    “pKa of a proton conducting water chain in photosystem II”
    Journal Pubmed
  52. Keisuke Saito*, Naoki Sakashita, and Hiroshi Ishikita
    Aust. J. Chem. 69 (2016) 991-998. doi:10.1071/CH16248
    “Energetics of the proton transfer pathway for tyrosine D in photosystem II”
    Journal
  53. Kento Motoyama, Hideaki Unno, Ai Hattori, Tomohiro Takaoka, Hiroshi Ishikita, Hiroshi Kawaide, Tohru Yoshimura, and Hisashi Hemmi*
    J. Biol. Chem. 292 (2017) 2457-2469. doi: 10.1074/jbc.M116.752535
    “A single amino acid mutation converts (R)-5-diphosphomevalonate decarboxylase into a kinase”
    Journal Pubmed
  54. Naoki Sakashita, Hiroshi C. Watanabe, Takuya Ikeda, and Hiroshi Ishikita*
    Photosynth. Res. 133 (2017) 75-85. doi: 10.1007/s11120-017-0347-1
    “Structurally conserved channels in cyanobacterial and plant photosystem II”
    Journal Pubmed
  55. Hiroshi C. Watanabe, Yuki Yamashita, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 114 (2017) 2916-2921. doi: 10.1073/pnas.1617615114 [Direct Submission, Edited by A. Warshel]
    “Electron transfer pathways in a multi-heme cytochrome MtrF”
    Journal Pubmed
  56. Ryo Hasegawa, Keisuke Saito, Tomohiro Takaoka, and Hiroshi Ishikita*
    Photosynth. Res. 133 (2017) 297-304. doi: 10.1007/s11120-017-0382-y
    “pKa of ubiquinone, menaquinone, phylloquinone, plastoquinone, and rhodoquinone in aqueous solution”
    Journal Pubmed
  57. Keisuke Kawashima and Hiroshi Ishikita*
    Biochemistry 56 (2017) 3019-3028. doi: 10.1021/acs.biochem.7b00082
    “Structural factors that alter the redox potential of quinones in cyanobacterial and plant photosystem I”
    Journal Pubmed
  58. Naoki Sakashita, Hiroshi C. Watanabe, Takuya Ikeda, Keisuke Saito, and Hiroshi Ishikita*
    Biochemistry 56 (2017) 3049-3057. doi: 10.1021/acs.biochem.7b00220
    “Origins of water molecules in the photosystem II crystal structure”
    Journal Pubmed
  59. Takuya Ikeda, Keisuke Saito, Ryo Hasegawa, and Hiroshi Ishikita*
    Angew. Chem. 129 (2017) 9279-9282. doi: 10.1002/ange.201705512
    Angew. Chem. Int. Ed. 56     (2017) 9151-9154. doi: 10.1002/anie.201705512
    “Existence of isolated H3O+ in the protein interior”
    Journal Pubmed
  60. Hiroshi C. Watanabe*, Maximilian Kubillus, Tomas Kubar, Robert Stach, Boris Mizaikoff, and Hiroshi Ishikita
    Phys. Chem. Chem. Phys. 19 (2017) 17985-17997. doi: 10.1039/C7CP01708A
    “Cation solvation with quantum chemical effects modeled by size-consistent multi-partitioning quantum mechanics/molecular mechanics method”
    Journal Pubmed
  61. Shinnosuke Kishi, Keisuke Saito, Yuki Kato, and Hiroshi Ishikita*
    Photosynth. Res. 134 (2017) 193-200. doi: 10.1007/s11120-017-0433-4
    “Redox potentials of ubiquinone, menaquinone, phylloquinone, and plastoquinone in aqueous solution”
    Journal Pubmed
  62. Hiroshi C. Watanabe, Yuki Yamashita, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 114 (2017) E10029-E10030. doi: 10.1073/pnas.1717048114
    “Molecular dynamics simulations do not provide functionally relevant values of redox potential in MtrF”
    Journal Pubmed
  63. Keisuke Saito*, Takumi Suzuki, and Hiroshi Ishikita
    J. Photochem. Photobiol. A 358 (2018) 422-431. doi: 10.1016/j.jphotochem.2017.10.003
    “Absorption-energy calculations of chlorophyll a and b with an explicit solvent model”
    Journal
  64. Keisuke Kawashima, Tomohiro Takaoka, Hiroki Kimura, Keisuke Saito, and Hiroshi Ishikita*
    Nat. Commun. 9 (2018) 1247. doi: 10.1038/s41467-018-03545-w
    “O2 evolution and recovery of the water-oxidizing enzyme”
    Journal Pubmed
  65. Keisuke Kawashima and Hiroshi Ishikita*
    Chem. Sci. 9 (2018) 4083-4092. doi 10.1039/C8SC00424B
    “Energetic insights into two electron transfer pathways in light-driven energy-converting enzymes”
    Journal Pubmed
  66. Yoshitaka Saga*, Keiya Hirota, Sayaka Matsui, Hitoshi Asakawa, Hiroshi Ishikita, and Keisuke Saito*
    Biochemistry 57 (2018) 3075-3083. doi: 10.1021/acs.biochem.8b00259
    “Selective removal of B800 bacteriochlorophyll a from the light-harvesting complex 2 of the purple photosynthetic bacterium Phaeospirillum molischianum”
    Journal Pubmed
  67. Keisuke Kawashima, Keisuke Saito, and Hiroshi Ishikita*
    Biochemistry 57 (2018) 4997-5004. doi: 10.1021/acs.biochem.8b00574
    “Mechanism of radical formation in the H-bond network of D1-Asn298 in photosystem II”
    Journal Pubmed
  68. Keiichi Kojima, Hiroshi C. Watanabe, Satoko Doi, Natsuki Miyoshi, Misaki Kato, Hiroshi Ishikita, Yuki Sudo*
    Biophys. Physicobiol. 15 (2018) 179-188. doi: 10.2142/biophysico.15.0_179
    “Mutational analysis of the conserved carboxylates of anion channelrhodopsin-2 (ACR2) expressed in Escherichia coli and their roles in anion transport”
    Journal Pubmed
  69. Keisuke Saito and Hiroshi Ishikita*
    Biochim. Biophys. Acta (Bioenergetics) 1860 (2019) 148059. doi: 10.1016/j.bbabio.2019.148059
    “Mechanism of protonation of the over-reduced Mn4CaO5 cluster in photosystem II”
    Journal Pubmed
  70. Hiroyuki Tamura*, Koki Azumaya, and Hiroshi Ishikita
    J. Phys. Chem. Lett. 10 (2019) 7623-7628. doi: 10.1021/acs.jpclett.9b03029
    “Long-range exciton diffusion via singlet revival mechanism”
    Journal Pubmed
  71. Keiichi Kojima, Tetsuya Ueta, Tomoyasu Noji, Keisuke Saito, Kanae Kanehara, Susumu Yoshizawa, Hiroshi Ishikita, Yuki Sudo*
    Sci. Rep. 10 (2020) 282. doi: 10.1038/s41598-019-57122-2
    “Vectorial proton transport mechanism of RxR, a phylogenetically distinct and thermally stable microbial rhodopsin”
    Journal Pubmed
  72. Manoj Mandal, Keisuke Kawashima, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 11 (2020) 249-255. doi: 10.1021/acs.jpclett.9b02831
    “Redox potential of the oxygen-evolving complex in the electron transfer cascade of photosystem II”
    Journal Pubmed
  73. Hiroyuki Tamura* and Hiroshi Ishikita
    J. Phys. Chem. A 124 (2020) 5081-5088. doi: 10.1021/acs.jpca.0c02228
    “Quenching of singlet oxygen by carotenoids via ultrafast super-exchange dynamics”
    Journal Pubmed
  74. Hiroyuki Tamura, Keisuke Saito, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 117 (2020) 6373-6382. doi: 10.1073/pnas.2000895117 [Direct Submission, Edited by P. Falkowski]
    “Acquirement of water-splitting ability and alteration of charge-separation mechanism in photosynthetic reaction centers”
    Journal Pubmed
  75. Naoki Sakashita, Hiroshi Ishikita, and Keisuke Saito*
    Phys. Chem. Chem. Phys. 22 (2020) 15831-15841. doi: 10.1039/d0cp00295j
    “Rigidly hydrogen-bonded water molecules facilitate proton transfer in photosystem II”
    Journal Pubmed
  76. Keisuke Saito, Minesato Nakagawa, and Hiroshi Ishikita*
    Commun. Chem. 3 (2020) 89. doi: 10.1038/s42004-020-00336-7
    “pKa of the ligand water molecules in the oxygen-evolving Mn4CaO5 cluster in photosystem II”
    Journal
  77. Keisuke Saito, Manoj Mandal, and Hiroshi Ishikita*
    Biochemistry 59 (2020) 3216-3224. doi: 10.1021/acs.biochem.0c00177
    “Energetics of ionized water molecules in the H-bond network near the Ca2+ and Cl– binding sites in photosystem II”
    Journal Pubmed
  78. Keiichi Kojima, Natsuki Miyoshi, Atsushi Shibukawa, Srikanta Chowdhury, Masaki Tsujimura, Tomoyasu Noji, Hiroshi Ishikita, Akihiro Yamanaka, and Yuki Sudo*
    J. Phys. Chem. Lett. 11 (2020) 6214-6218. doi: 10.1021/acs.jpclett.0c01406
    “Green-sensitive, long-lived, step-functional anion channelrhodopsin-2 variant as a high-potential neural silencing tool”
    Journal Pubmed
  79. Keisuke Saito*, Koji Mitsuhashi, and Hiroshi Ishikita*
    J. Photochem. Photobiol. A 402 (2020) 112799. doi: 10.1016/j.jphotochem.2020.112799
    “Dependence of the chlorophyll wavelength on the orientation of a charged group: why does the accessory chlorophyll have a low site energy in photosystem II?”
    Journal
  80. Keisuke Saito, Manoj Mandal, and Hiroshi Ishikita*
    Phys. Chem. Chem. Phys. 22 (2020) 25467-25473. doi: 10.1039/D0CP04265J
    “Redox potentials along the redox-active low-barrier H-bonds in electron transfer pathways”
    Journal Pubmed
  81. Manoj Mandal, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 11 (2020) 10262-10268. doi: 10.1021/acs.jpclett.0c02868
    “The nature of the short oxygen-oxygen distance in the Mn4CaO6 complex of the photosystem II crystals”
    Journal Pubmed
  82. Masaki Tsujimura and Hiroshi Ishikita*
    J. Phys. Chem. B 124 (2020) 11819-11826. doi: 10.1021/acs.jpcb.0c08910
    “Insights into the protein functions and absorption wavelengths of microbial rhodopsins”
    Journal Pubmed
  83. Masaki Tsujimura, Tomoyasu Noji, Keisuke Saito, Keiichi Kojima, Yuki Sudo, and Hiroshi Ishikita*
    Biochim. Biophys. Acta (Bioenergetics) 1862 (2021) 148349. doi: 10.1016/j.bbabio.2020.148349
    “Mechanism of absorption wavelength shifts in anion channelrhodopsin-1 mutants”
    Journal Pubmed
  84. Hiroshi Kuroda1, Keisuke Kawashima1, Kazuyo Ueda, Takuya Ikeda, Keisuke Saito, Ryo Ninomiya, Chisato Hida, Yuichiro Takahashi*, Hiroshi Ishikita*
    Biochim. Biophys. Acta (Bioenergetics) 1862 (2021) 148329. doi: 10.1016/j.bbabio.2020.148329
    “Proton transfer pathway from the oxygen-evolving complex in photosystem II substantiated by extensive mutagenesis”
    1These authors contributed equally to this work.
    Journal Pubmed
  85. Masaki Tsujimura* and Hiroshi Ishikita*
    J. Biol. Chem. 296 (2021) 100459. doi: 10.1016/j.jbc.2021.100459
    “Identification of intermediate conformations in the photocycle of the light-driven sodium-pumping rhodopsin KR2”
    Journal Pubmed
  86. Koji Mitsuhashi, Hiroyuki Tamura, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. B 125 (2021) 2879-2885. doi: 10.1021/acs.jpcb.0c10885
    “Nature of asymmetric electron transfer in the symmetric pathways of photosystem I”
    Journal Pubmed
  87. Manoj Mandal, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 12 (2021) 4032-4037. doi: 10.1021/acs.jpclett.1c00814
    “Two distinct oxygen-radical conformations in the X‑ray free electron laser structures of photosystem II”
    Journal Pubmed
  88. Hiroyuki Tamura*, Keisuke Saito, and Hiroshi Ishikita
    Chem. Sci. 12 (2021) 8131-8140. doi: 10.1039/D1SC01497H
    “The origin of unidirectional charge separation in photosynthetic reaction centers: nonadiabatic quantum dynamics of exciton and charge in the pigment-protein complexes”
    Journal Pubmed
  89. Keisuke Saito*, Minesato Nakagawa, Manoj Mandal, and Hiroshi Ishikita*
    Photosynth. Res. 148 (2021) 153-159. doi: 10.1007/s11120-021-00846-y
    “Role of redox-inactive metals in controlling the redox potential of heterometallic manganese-oxido clusters”
    Journal Pubmed
  90. Yu Sugo, Keisuke Saito, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 118 (2021) e2103203118. doi: 10.1073/pnas.2103203118
    “Mechanism of the formation of proton transfer pathways in photosynthetic reaction centers”
    Journal Pubmed
  91. Tomoki Kanda1, Keisuke Saito1, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 12 (2021) 7431-7438. doi: 10.1021/acs.jpclett.1c01896
    “Electron acceptor-donor Fe sites in the iron-sulfur cluster of photosynthetic electron-transfer pathways”
    1These authors contributed equally to this work.
    Journal Pubmed
  92. Katsumori Segawa1, Atsuo Kikuchi1, Tomoyasu Noji, Yuki Sugiura, Keita Hiraga, Chigure Suzuki, Kazuhiro Haginoya, Yasuko Kobayashi, Mitsuhiro Matsunaga, Yuki Ochiai, Kyoko Yamada, Takuo Nishimura, Shinya Iwasawa, Wataru Shoji, Fuminori Sugihara, Kohei Nishino, Hidetaka Kosako, Masahito Ikawa, Yasuo Uchiyama, Makoto Suematsu, Hiroshi Ishikita, Shigeo Kure, Shigekazu Nagata*
    J. Clin. Invest. 131 (2021) e148005. doi: 10.1172/JCI148005
    “A sublethal mutation in ATP11A that causes aberrant phosphatidylcholine flipping in plasma membranes”
    1These authors contributed equally to this work.
    Journal Pubmed
  93. Yasunori Saitoh1, Namiki Mitani-Ueno1, Keisuke Saito1, Kengo Matsuki, Sheng Huang, Lingli Yang, Naoki Yamaji, Hiroshi Ishikita, Jian-Ren Shen, Jian Feng Ma, and Michihiro Suga*
    Nat. Commun. 12 (2021) 6236. doi: 10.1038/s41467-021-26535-x
    “Structural basis for high selectivity of a rice silicon channel Lsi1”
    1These authors contributed equally to this work.
    Journal Pubmed
  94. Taichi Tsuneishi1, Masataka Takahashi1, Masaki Tsujimura1, Keiichi Kojima, Hiroshi Ishikita, Yasuo Takeuchi, and Yuki Sudo*
    Front. Mol. Biosci. 8 (2021) 794948. doi: 10.3389/fmolb.2021.794948
    “Exploring the retinal binding cavity of archaerhodopsin-3 by replacing the retinal chromophore with a dimethyl phenylated derivative”
    1These authors contributed equally to this work.
    Journal Pubmed
  95. Masaki Tsujimura1, Keiichi Kojima1, Shiho Kawanishi, Yuki Sudo*, and Hiroshi Ishikita*
    eLife 10 (2021) e72264. doi: 10.7554/eLife.72264
    “Proton transfer pathway in anion channelrhodopsin-1”
    1These authors contributed equally to this work.
    Journal Pubmed
  96. Hiroyuki Tamura*, Keisuke Saito, and Hiroshi Ishikita
    J. Phys. Chem. B 125 (2021) 13460-13466. doi: 10.1021/acs.jpcb.1c09538
    “Long-range electron tunneling from the primary to secondary quinones in photosystem II enhanced by hydrogen bonds with non-heme Fe complex”
    Journal Pubmed
  97. Manoj Mandal, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. B 126 (2022) 123-131. doi: 10.1021/acs.jpcb.1c09176
    “Requirement of chloride for downhill electron transfer pathway from the water-splitting center in natural photosynthesis”
    Journal Pubmed
  98. Yutaro Saito, Hiroyuki Yatabe, Iori Tamura, Yohei Kondo, Ryo Ishida, Tomohiro Seki, Keita Hiraga, Akihiro Eguchi, Yoichi Takakusagi, Keisuke Saito, Hiroshi Ishikita, Kazutoshi Yamamoto, Murali C. Krishna*, and Shinsuke Sando*
    Sci. Adv. 8 (2022) eabj2667. doi: 10.1126/sciadv.abj2667
    “Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo”
    Journal Pubmed
  99. Manoj Mandal, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Soc. Jpn. 91 (2022) 091012. doi: 10.7566/JPSJ.91.091012
    “Release of electrons and protons from substrate water molecules at the oxygen-evolving complex in photosystem II”
    Journal
  100. Tomoki Kanda, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. B 126 (2022) 3059-3066. doi: 10.1021/acs.jpcb.2c01320
    “Mechanism of mixed-valence Fe2.5+…Fe2.5+ formation in Fe4S4 clusters in the ferredoxin binding motif”
    Journal Pubmed
  101. Masaki Tsujimura, Hiroyuki Tamura, Keisuke Saito, and Hiroshi Ishikita*
    iScience 25 (2022) 104247. doi: 10.1016/j.isci.2022.104247
    “Absorption wavelength along chromophore low-barrier hydrogen bonds”
    Journal Pubmed
  102. Manoj Mandal, Keisuke Saito, and Hiroshi Ishikita*
    ACS Phys. Chem Au 2 (2022) 423-429. doi: 10.1021/acsphyschemau.2c00019
    “Release of the proton and formation of the low-barrier hydrogen bond between tyrosine D and D2-His189 in photosystem II”
    Journal Pubmed
  103. Keisuke Saito*, Tianyang Xu, and Hiroshi Ishikita*
    J. Phys. Chem. B 126 (2022) 4999-5006. doi: 10.1021/acs.jpcb.2c02193
    “Correlation between C=O stretching vibrational frequency and pKa shift of carboxylic acids”
    Journal Pubmed
  104. Yu Sugo, Keisuke Saito, and Hiroshi Ishikita*
    Biochemistry 61 (2022) 1836-1843. doi: 10.1021/acs.biochem.2c00324
    “Conformational changes and H-bond rearrangements during quinone release in photosystem II”
    Journal Pubmed
  105. Ko Imaizumi, Taishi Nishimura, Ryo Nagao, Keisuke Saito, Takeshi Nakano, Hiroshi Ishikita, Takumi Noguchi, and Kentaro Ifuku*
    PNAS Nexus 1 (2022) pgac136. doi: 10.1093/pnasnexus/pgac136
    “D139N mutation of PsbP enhances the oxygen-evolving activity of photosystem II through stabilized binding of a chloride ion”
    Journal Pubmed
  106. Hiroyuki Tamura*, Hiroki Takezawa, Makoto Fujita, and Hiroshi Ishikita*
    Phys. Chem. Chem. Phys. 24 (2022) 21367-21371. doi: 10.1039/D2CP03126D
    “Self-assembled coordination cage enhances reactivity of confined amides via mechanical bond-twisting”
    Journal Pubmed
  107. Yu Sugo and Hiroshi Ishikita*
    Front. Plant Sci. 13 (2022) 934736. doi: 10.3389/fpls.2022.934736
    “Proton-mediated photoprotection mechanism in photosystem II”
    Journal Pubmed
  108. Keisuke Saito*, Hiroyuki Mino, Shunya Nishio, and Hiroshi Ishikita*
    PNAS Nexus 1 (2022) pgac221. doi: 10.1093/pnasnexus/pgac221
    “Protonation structure of the closed-cubane conformation of the O2-evolving complex in photosystem II”
    Journal Pubmed
  109. Tomoki Kanda and Hiroshi Ishikita*
    Biochemistry 61 (2022) 2621-2627. doi: 10.1021/acs.biochem.2c00524
    “Energetics of the electron transfer pathways in the homodimeric photosynthetic reaction center”
    Journal Pubmed
  110. Tomoyasu Noji* and Hiroshi Ishikita
    J. Phys. Chem. B 126 (2022) 9945-9955. doi: 10.1021/acs.jpcb.2c04359
    “Mechanism of absorption wavelength shift of bacteriorhodopsin during photocycle”
    Journal Pubmed
  111. Yu Sugo, Hiroyuki Tamura, and Hiroshi Ishikita*
    J. Phys. Chem. B 126 (2022) 9549-9558. doi: 10.1021/acs.jpcb.2c05713
    “Electron transfer route between quinones in type-II reaction centers”
    Journal Pubmed
  112. Masaki Tsujimura*, Yoshihiro Chiba, Keisuke Saito, and Hiroshi Ishikita*
    Commun. Biol. 5 (2022) 1336. doi: 10.1038/s42003-022-04311-x
    “Proton transfer and conformational changes along the hydrogen bond network in heliorhodopsin”
    Journal Pubmed
  113. Sho Koyasu, Shoichiro Horita, Keisuke Saito, Minoru Kobayashi, Hiroshi Ishikita, Christalle C.T. Chow, Gouki Kambe, Shigeto Nishikawa, Toshi Menju, Akiyo Morinibu, Yasushi Okochi, Yoshiaki Tabuchi, Yasuhito Onodera, Norihiko Takeda, Hiroshi Date, Gregg L. Semenza, Ester M. Hammond, and Hiroshi Harada*
    EMBO rep. 24 (2023) e54042. doi: 10.15252/embr.202154042
    “ZBTB2 links p53-deficiency to HIF-1-mediated hypoxia signaling for cancer aggressiveness”
    Journal Pubmed
  114. Hiroyuki Tamura*, Keisuke Saito, Shunya Nishio, and Hiroshi Ishikita*
    J. Phys. Chem. B 127 (2023) 205-211. doi: 10.1021/acs.jpcb.2c08246
    “Electron-transfer route in the early oxidation states of the Mn4CaO5 cluster in photosystem II”
    Journal Pubmed
  115. Masaki Tsujimura*, Minaka Sugano, Hiroshi Ishikita, and Keisuke Saito*
    J. Phys. Chem. B 127 (2023) 505-513. doi: 10.1021/acs.jpcb.2c07232
    “Mechanism of absorption wavelength shift depending on the protonation state of the acrylate group in chlorophyll c”
    Journal Pubmed
  116. Keisuke Saito*, Koji Mitsuhashi, Hiroyuki Tamura*, and Hiroshi Ishikita*
    Biophys. J. 22 (2023) 470-483. doi: 10.1016/j.bpj.2023.01.002
    “Quantum mechanical analysis of excitation energy transfer couplings in photosystem II”
    Journal Pubmed
  117. Tomoki Kanda and Hiroshi Ishikita*
    Biochemistry 62 (2023) 934-941. doi: 10.1021/acs.biochem.2c00689
    “Energetic diversity in the electron transfer pathways of type I photosynthetic reaction centers”
    Journal Pubmed
  118. Manoj Mandal*, Keisuke Saito, and Hiroshi Ishikita*
    Phys. Chem. Chem. Phys. 25 (2023) 6473-6480. doi: 10.1039/D2CP05036F
    “Substitution of Ca2+ and changes in the H-bond network near the oxygen-evolving complex of photosystem II”
    Journal Pubmed
  119. Keisuke Saito*, Shu Nakao, and Hiroshi Ishikita*
    Front. Plant Sci. 14 (2023)1029674. doi: 10.3389/fpls.2023.1029674
    “Identification of the protonation and oxidation states of the oxygen-evolving complex in the low-dose X-ray crystal structure of photosystem II”
    Journal Pubmed
  120. Yu Sugo and Hiroshi Ishikita*
    Biochemistry 62 (2023) 1544-1552. doi: 10.1021/acs.biochem.3c00013
    “Mechanism of asparagine-mediated proton transfer in photosynthetic reaction centers”
    Journal Pubmed
  121. Tomoki Kanda and Hiroshi Ishikita*
    J. Phys. Chem. B 127 (2023) 4998-5004. doi: 10.1021/acs.jpcb.3c01071
    “Redox potentials of iron-sulfur clusters in type I photosynthetic reaction centers”
    Journal Pubmed
  122. Yoshihiro Chiba, Masaki Tsujimura, Keisuke Saito, and Hiroshi Ishikita*
    Biochemistry 62 (2023) 2363–2370, doi: 10.1021/acs.biochem.3c00193
    “pH-dependent binding and releasing mechanism of acetate in the inner water cavity of heliorhodopsin”
    Journal
  123. Masahiro Saito, Keisuke Saito, and Hiroshi Ishikita*
    iScience 26 (2023) 107352. doi: 10.1016/j.isci.2023.107352
    “Structural and energetic insights into Mn-to-Fe substitution in the oxygen-evolving complex”
    Journal pubmed
  124. Keisuke Saito*, Shunya Nishio, Mizue Asada, Hiroyuki Mino, and Hiroshi Ishikita*
    PNAS Nexus 2 (2023) pgad244. doi: 10.1093/pnasnexus/pgad244
    “Insights into the protonation state and spin structure for the g=2 multiline EPR signal of the oxygen-evolving complex”
    Journal Pubmed
  125. Gai Nishikawa, Yu Sugo, Keisuke Saito, and Hiroshi Ishikita*
    eLife12 (2023) e88955. doi: 10.7554/eLife.88955
    “Absence of electron transfer-associated changes in the time-dependent X-ray free-electron laser structures of the photosynthetic reaction center”
    Journal Pubmed
  126. Masaki Tsujimura*, Keisuke Saito, and Hiroshi Ishikita*
    Biophys. J. 122 (2023) 4336-4347. doi: 10.1016/j.bpj.2023.10.012
    “Stretching vibrational frequencies and pKa differences in H-bond networks of protein environments”
    Journal Pubmed
  127. Tomoyasu Noji, Hiroyuki Tamura, Hiroshi Ishikita, and Keisuke Saito*
    J. Phys. Chem. B 127 (2023) 10351-10359. doi: 10.1021/acs.jpcb.3c06483
    “Difference in the charge-separation energetics between distinct conformers in the PixD photoreceptor”
    Journal Pubmed
  128. Yusuke Kato, Hiroshi Kuroda, Shin-Ichiro Ozawa, Keisuke Saito, Vivek Dogra, Martin Scholz, Guoxian Zhang, Catherine de Vitry, Hiroshi Ishikita, Chanhong Kim, Michael Hippler, Yuichiro Takahashi, and Wataru Sakamoto
    eLife12 (2023) RP88822. doi:10.7554/eLife.88822
    “Characterization of tryptophan oxidation affecting D1 degradation by FtsH in the photosystem II quality control of chloroplasts”
    Journal Pubmed
  129. Keisuke Saito*, Shunya Nishio, and Hiroshi Ishikita*
    PNAS Nexus 2 (2023) pgad423. doi: 10.1093/pnasnexus/pgad423
    “Interplay of two low-barrier hydrogen bonds in long-distance proton-coupled electron transfer for water oxidation”
    Journal Pubmed
  130. Gai Nishikawa, Keisuke Saito, and Hiroshi Ishikita*
    Biochemistry 63 (2024) 1206-1213. doi: 10.1021/acs.biochem.4c00010
    “Modulation of electron transfer branches by atrazine and triazine herbicides in photosynthetic reaction centers”
    Journal Pubmed
  131. Keisuke Saito, Yang Chen, and Hiroshi Ishikita*
    J. Phys. Chem. B 128 (2024) 4728-4734. doi: 10.1021/acs.jpcb.4c01997
    “Exploring the deprotonation process during incorporation of a ligand water molecule at the dangling Mn site in photosystem II”
    Journal Pubmed
  132. Tomoyasu Noji, Yoshihiro Chiba, Keisuke Saito, and Hiroshi Ishikita*
    Biochemistry 63 (2024) 1505-1512. doi: 10.1021/acs.biochem.4c00182
    “Energetics of the H-bond network in Exiguobacterium sibiricum rhodopsin”
    Journal Pubmed
  133. Hiroyuki Tamura, Takahiro Nakama, Anouk Rossen, Hiroshi Ishikita, and Makoto Fujita*
    Chem. Lett. 53 (2024) upae101. doi: 10.1093/chemle/upae101
    “Organic solvent-induced structural changes in a protein confined in a giant coordination cage”
    Journal
  134. Takayuki Nagae, Mitsuhiro Takeda, Tomoyasu Noji, Keisuke Saito, Hiroshi Aoyama, Yohei Miyanoiri, Yutaka Ito, Masatsune Kainosho, Yuu Hirose, Hiroshi Ishikita*, Masaki Mishima*.
    Proc. Natl. Acad. Sci. U. S. A. 121 (2024) e2404472121. doi: 10.1073/pnas.2404472121
    “Direct evidence for a deprotonated lysine serving as a “H-bond acceptor” in a photoreceptor protein”
    Journal Pubmed
  135. Tomoyasu Noji, Keisuke Saito, and Hiroshi Ishikita*
    Biophys. J. 123 (2024) 3375-3385. doi: 10.1016/j.bpj.2024.08.001
    “Molecular origins of absorption wavelength variation among phycocyanobilin-binding proteins”
    Journal Pubmed
  136. Tomoyasu Noji, Keisuke Saito, and Hiroshi Ishikita*
    Commun. Chem. 7 (2024) 192. doi: 10.1038/s42004-024-01281-5
    “Absence of a link between stabilized charge-separated state and structural changes proposed from crystal structures of a photosynthetic reaction center”
    Journal Pubmed
  137. Gouki Kambe, Minoru Kobayashi, Hiroshi Ishikita, Sho Koyasu, Ester M. Hammond, Hiroshi Harada*
    Biochem. Biophys. Res. Commun. 733 (2024) 150604. doi: 10.1016/j.bbrc.2024.150604
    “ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1”
    Journal Pubmed
  138. Keisuke Saito*, Hiroyuki Tamura, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 15 (2024) 9183-9192. doi: 10.1021/acs.jpclett.4c02232
    “Superexchange electron transfer and protein matrix in the charge-separation process of photosynthetic reaction centers”
    Journal Pubmed
  139. Ruri Nihara, Keisuke Saito, Hiroshi Kuroda, Yasuto Komatsu, Yang Chen, Hiroshi Ishikita*, and Yuichiro Takahashi*
    Biochim. Biophys. Acta (Bioenergetics) 1866 (2024)149507. doi: 10.1016/j.bbabio.2024.149507
    “D1-Tyr246 and D2-Tyr244 in photosystem II: Insights into bicarbonate binding and electron transfer from QA•− to QB”
    Journal Pubmed
  140. David C. Calianese1, Tomoyasu Noji1, Jennifer A. Sullivan, Kelly Schoch, Vandana Shashi, Vanda McNiven, Luiza Lorena Pires Ramos, Albena Jordanova, Judit Kárteszi, Hiroshi Ishikita, and Shigekazu Nagata*
    Proc. Natl. Acad. Sci. U. S. A. 121 (2024) e2415755121
    “Substrate specificity controlled by the exit site of human P4-ATPases, revealed by de novo point mutations in neurological disorders”
    1These authors contributed equally to this work.
    Journal Pubmed
  141. Tomoyasu Noji, Keisuke Saito, and Hiroshi Ishikita*
    Biochemistry (2024) doi: 10.1021/acs.biochem.4c00521
    “How the electron-transfer cascade is maintained in chlorophyll-d containing photosystem I”

OTHERS

  1. Irina Karyagina1, Yulia Pushkar, Dietmar Stehlik, Art van der Groot, Hiroshi Ishikita, Ernst-Walter Knapp, Bharat Jagannathan, Rufat Agalarov, and John H. Golbeck*
    Photosynthesis. Energy from the Sun (2008) pp. 101-104 (DOI: 10.1007/978-1-4020-6709-9_23)
    “The influence of aspartate 575PsaB on the midpoint potentials of phylloquinones A1A/A1B and the Fx iron-sulfur cluster in photosystem I”
  2. Keisuke Saito and Hiroshi Ishikita*
    Nature Precedings (2011) doi:10.1038/npre.2011.6486.1
    “Cationic state distributions over chlorophyll pairs in photosystem I and II”
  3. Hiroshi Ishikita*
    Handbook of Flavoproteins Vol.2. (Verlag Walter de Gruyter GmbH & Co. KG, Berlin) pp321-333
    “Contributions of protein environment to the reduction potentials of flavin-containing proteins”
  4. Hiroshi Ishikita*
    Kyoto University Research Activities (2013) Vol2, No.3, pp23
    “Research Frontiers: How Do Green Plants Produce O2 from Water?”
  5. Hiroshi Ishikita*
    Oxygen Production and Reduction in Artificial and Natural Systems (James Barber, Alexander V Ruban, and Peter J Nixon, Eds.) (2019) pp 191-208, World Scientific, doi: 10.1142/9789813276925_0010, ISBN: 978-981-3276-93-2
    “Protein Environment that Facilitates Proton Transfer and Electron Transfer in Photosystem II”
  6. Hiroshi Ishikita* and Keisuke Saito
    Microbial Photosynthesis (Wang, Qiang, Ed.) (2020) pp 115-120, Springer Nature, doi: 10.1007/978-981-15-3110-1_5, Online ISBN 978-981-15-3110-1, Print ISBN 978-981-15-3109-5
    “Redox potentials of quinones in aqueous solution: Relevance to redox potentials in protein environments”
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